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Medicinal Chemistry Approaches to Personalized Medicine (Hardcover)
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Medicinal Chemistry Approaches to Personalized Medicine (Hardcover)
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Edited by two renowned medicinal chemists who have pioneered the
development of personalized therapies in their respective fields,
this authoritative analysis of what is already possible is the
first of its kind, and the only one to focus on drug development
issues. Numerous case studies from the first generation of
"personalized drugs" are presented, highlighting the challenges and
opportunities for pharmaceutical development. While the majority of
these examples are taken from the field of cancer treatment, other
key emerging areas, such as neurosciences and inflammation, are
also covered. With its careful balance of current and future
approaches, this handbook is a prime knowledge source for every
drug developer, and one that will remain up to date for some time
to come. From the content: * Discovery of Predictive Biomarkers for
Anticancer Drugs * Discovery and Development of Vemurafenib *
Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic
Targets in Cancer * From Human Genetics to Drug Candidates: An
Industrial Perspective on LRRK2 Inhibition as a Treatment for
Parkinson's Disease * Therapeutic Potential of Kinases in Asthma *
DNA Damage Repair Pathways and Synthetic Lethality * Medicinal
Chemistry in the Context of the Human Genome and many more
General
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