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Protein Binding of Angiotensin Receptor II Antagonist (Paperback)
Loot Price: R1,220
Discovery Miles 12 200
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Protein Binding of Angiotensin Receptor II Antagonist (Paperback)
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Donate to Against Period Poverty
Total price: R1,240
Discovery Miles: 12 400
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This book is related to a study where binding of Losartan Potassium
and Valsartan, two anti-hypertensive drugs to Bovine Serum Albumin
(BSA)were studied by Equilibrium Dialysis Method.The binding of
Losartan Potassium and Valsartan was characterized by two sets of
Association Constants.Losartan Potassium showed slightly higher
affinity towards BSA than Valsartan.Different analyses of binding
to BSA suggested the presence of one high affinity site and four to
five low affinity sites for Losartan Potassium and
Valsartan.Site-specific probe displacement data implied that both
Losartan Potassium and Valsartan primarily bind to site I, the
warfarin site, while the low affinity site of these two drugs was
site II, the Benzodiazepine site on BSA.During concurrent
administration of Losartan potassium and Valsartan, both drugs have
been found to increase the respective free concentration of one
another causing reduced binding to BSA.This book will be helpful
for the students and researchers of Pharmacy discipline specially
those who are interested or engaged in research related to Protein
Binding.
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