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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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G Protein Signaling Mechanisms in the Retina (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R3,486
Discovery Miles 34 860
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G Protein Signaling Mechanisms in the Retina (Paperback, Softcover reprint of the original 1st ed. 2014)
Series: Springer Series in Vision Research, 3
Expected to ship within 10 - 15 working days
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The main purpose of this volume is to provide a focused analysis of
the function of the G protein-coupled signaling pathways that
operate in the interconnected network of retinal neurons as they
detect and encode the information carried by light. The
organization of this volume will generally follow the path of
signal flow in the retina. First we will describe recent advances
in understanding the phototransduction cascade of rod and cone
photoreceptors, which use signaling cascade based on the GPCR
rhodopsin to transduce incident light into neural activity.
Chapters will be devoted to unique specializations of the two major
types of photosensitive cells that comprise the predominant input
for our spatial and color vision. Subsequently, the mechanisms of
synaptic information encoding by retinal ON bipolar cells will be
described, where the GPCR mGluR6 plays a fundamental role. Chapters
in this section will examine macromolecular organization of the
mGluR6 signaling pathway as well as current understanding of its
function. The functional characteristics of this signaling
mechanism will be explored in detail. Additionally, this section
will cover the role of dopamine receptors in modulating signal
transmission between photoreceptors and ON-bipolar cells. Finally,
chapters will be focused on the output neurons of the inner retina,
ganglion cells, where the components of the emerging GPCR
melanopsin cascade in intrinsically photosensitive ganglion cells
will be detailed. Collectively these mechanisms allow the retina to
represent visual space over a wide range of light intensities.
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