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Transglutaminases - Multiple Functional Modifiers and Targets for New Drug Discovery (Hardcover, 1st ed. 2015)
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Transglutaminases - Multiple Functional Modifiers and Targets for New Drug Discovery (Hardcover, 1st ed. 2015)
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This book presents basic and extensive information on the
physiological and pathological significance of the
protein-modifying enzymes, transglutaminases, which are involved in
multiple biological events by catalyzing a unique and important
posttranslational modification reaction, cross-linking of proteins,
and interacting with a large number of proteins inside and outside
of cells. Although several of their essential physiological roles
have been revealed, many unknown and so far not fully understood
functions have remained. In humans, there are eight active isozymes
having distinct tissue and subcellular distribution patterns with
different substrates and physiological roles. Accordingly, aberrant
regulation of the enzyme reactions or expression may lead to or has
been implicated in various pathologies including neurodegeneration,
fibrosis, cancer, inflammation, celiac disease, and hemostasis
disorders.To provide those who are new to the field with basic
knowledge and recent information on transglutaminase structures and
reactions, the mechanism by which transglutaminases modify
substrate proteins and their contributions to multiple biological
phenomena as well as disease phenotypes, the publication of the
present transglutaminase book was planned, to consist of review
articles by 17 expert investigators working in this exciting area
of research. The book contains detailed information related to
several transglutaminases from aspects in chemical and cellular
biology, medical sciences, and biotechnology that will also supply
starting points for drug discovery. Although many prominent
findings have been published in recent years, this type of
comprehensive review book has been missing in the scientific
literature. This volume will be useful for investigators who either
currently work on or will start addressing transglutaminase-related
research, and beyond that, for a broad audience in the scientific
community.
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