Books > Science & Mathematics > Biology, life sciences > Molecular biology
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VEGF Signaling - Methods and Protocols (Hardcover, 1st ed. 2015)
Loot Price: R2,821
Discovery Miles 28 210
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VEGF Signaling - Methods and Protocols (Hardcover, 1st ed. 2015)
Series: Methods in Molecular Biology, 1332
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This volume provides a collection of protocols for studying and
manipulating VEGF signaling pathways in vitro and in vivo, and in
particular, aims to present a range of both firmly established and
newly emerging technologies, including those that are amenable to
aiding in drug discovery or pre-clinical investigations. Each of
the three sections begins with an introductory overview followed by
supporting relevant methods. A major advantage of this book is that
each chapter not only contains methodological detail rarely seen in
other literature, but also contains a section on key notes and
troubleshooting advice. Part I focuses on quantification of
specific VEGF and VEGF receptor isoforms, beginning with a summary
on VEGF splice variants, their function and their regulation. Part
II relates to the study of VEGF dependent signaling in vitro,
starting with a comprehensive overview of VEGF-mediated signal
transduction in the cardiovascular system that highlights recent
discoveries in the field. Part III first details genetic mouse
models, then discusses techniques for studying physiological
angiogenesis in the developing mouse embryo. Written in the highly
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols and tips on troubleshooting and
avoiding known pitfalls. Cutting-edge and thorough, VEFG Signaling:
Methods and Protocols is a useful tool for researching and
understanding the basic biology of VEGF signaling and translating
it into the clinic.
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