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Imaging Biomarkers - Development and Clinical Integration (Hardcover, 1st ed. 2017)
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Imaging Biomarkers - Development and Clinical Integration (Hardcover, 1st ed. 2017)
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This is the first book to cover all aspects of the development of
imaging biomarkers and their integration into clinical practice,
from the conceptual basis through to the technical aspects that
need to be considered in order to ensure that medical imaging can
serve as a powerful quantification instrument capable of providing
valuable information on organ and tissue properties. The process of
imaging biomarker development is considered step by step, covering
proof of concept, proof of mechanism, image acquisition, image
preparation, imaging biomarker analysis and measurement, detection
of measurement biases (proof of principle), proof of efficacy and
effectiveness, and reporting of results. Sources of uncertainty in
the accuracy and precision of measurements and pearls and pitfalls
in gold standards and biological correlation are discussed. In
addition, practical use cases are included on imaging biomarker
implementation in brain, oncologic, cardiovascular,
musculoskeletal, and abdominal diseases. The authors are a
multidisciplinary team of expert radiologists and engineers, and
the book will be of value to all with an interest in the
quantitative imaging of biomarkers in personalized medicine.
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