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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology
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Pharmacodynamic Models of Selected Toxic Chemicals in Man - Volume 2: Routes of Intake and Implementation of Pharmacodynamic Models (Hardcover, 1986 ed.)
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Pharmacodynamic Models of Selected Toxic Chemicals in Man - Volume 2: Routes of Intake and Implementation of Pharmacodynamic Models (Hardcover, 1986 ed.)
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This report contains the results of a study undertaken by
Associated Nuclear Services (ANS) for the Directorate General of
Employment, Social Affairs and Education of the Commission of the
European Communities (CEC). This study was entitled "Dynamics of
Selected Toxic Materials in Man". vii 2 Summary This report
presents results from the second phase of a study on the metabolism
of selected actual and potential human carcin- ogens. In the first
phase of this work a comprehensive review of literature relating to
the metabolism of these materials was under- taken and
pharmacokinetic models were proposed to represent that meta-
bolism. It was suggested that these models, and the reviews on
which they were based, would provide information relevant to the
development of monitoring programmes and in the interpretation of
dose-response data. In the second phase of the study, attention has
been concen- trated on the implementation of the models proposed
for the various substances reviewed, i.e. arsenic, beryllium,
cadmium, lead, nickel, chromium, asbestos, benzene, vinyl chloride
monomer, benzidine and its congeners, carbon tetrachloride and
methyl iodide. However, this programme has been supplemented by an
on-going review of the relevant literature on these substances and
a detailed analysis of the applica- bili ty of the pharmacokinetic
models used for the organs of intake, i.e. the lung and
gastrointestinal tract.
General
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