Vascular endothelial growth factor (VEGF) is one of the most potent
and specific angiogenic factors. The physiologic roles of VEGF in
humans include neovascularisation and endometrium implantation, and
in pathological processes VEGF has been involved in the initiation,
growth, and metastasis of tumors. In this book, the authors discuss
the biology, regulation and clinical significance of VEGF. Topics
include VEGF signalling and multi-drug resistance transporter
(ABCB1); clinical imaging of tumour vascularity as a biomarker
during anti-VEGF therapy; VEGF and kidney cancer; the effect of
VEGF on oocyte maturation and embryo development of bovine and
ovine in vitro and its mechanisms; physiological functions of VEGF
in the retina; VEGF in the regulation of gingival venule diameter
under physiological and pathological circumstances; regulation of
VEGF expression by progesterone and estradiol in normal and cancer
cells; ethanol stimulated angiogenesis via VEGF and protection from
ischemia and reperfusion injury; and the role of VEGF in major
depression.
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