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Handbook Of Immunological Properties Of Engineered Nanomaterials (In 3 Volumes) (Hardcover, Second Edition)
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Handbook Of Immunological Properties Of Engineered Nanomaterials (In 3 Volumes) (Hardcover, Second Edition)
Series: Frontiers in Nanobiomedical Research, 6
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This unique book provides comprehensive overview of the field of
immunology related to engineered nanomaterials used for biomedical
applications. It contains literature review, case studies and
protocols. The book can serve as a source of information about
nanoimmunotoxicology for both junior scientists and experts in the
field. The authors have more than 10 years of experience with
preclinical characterization of engineered nanomaterials used for
medical applications, and they share their experience with the
readers. In addition, the international team of experts in the
field provides the opinion and share the expertise on individual
topics related to nanoparticle physicochemical characterization,
hematocompatibility, and effects on the immune cell function . The
second edition contains updated chapters from the first edition
plus new chapters covering areas of tumor immunology, nanoparticle
interaction with lymphatic system, mathematical modeling of protein
corona, utilization of nanoparticles for the delivery of antiviral
drugs, extensive analysis of nanoparticle anti-inflammatory and
immunosuppressive properties, novel ways of protecting therapeutic
nanoparticles from the immune recognition, as well as case studies
regarding nanoparticle sterilization, complement activation,
protein binding and immunotherapy of cancer. The second edition
comes in 3 volumes. Volume 1 is focused on nanoparticle
characterization, sterility and sterilization, pyrogen
contamination and depyrigenation. It also contains overview of
regulatory guidelines, protocols for in vitro and in vivo
immunotoxicity studies, and correlation between in vitro and in
vivo immunoassays. Volume 2 is focused on hematocompatibility of
nanomaterials. It provides comprehensive review and protocols for
investigating nanoparticle interaction with erythrocytes,
platelets, endothelial cells, plasma coagulation factors and plasma
proteins forming so called 'corona' around nanoparticles. Volume 3
is dedicated to nanoparticle interaction with and effects on the
immune cell function. It also contains examples of nanoparticle use
for delivery of antiviral and anti-inflammatory drugs.
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