In Neurology of Autism, Mary Coleman, Catalina Betancur, G. Robert
DeLong, Christopher Gillberg, Yoshiko Nomura, Lorenzo Pavone,
Martin Ruggieri, and Michele Zappella use the tools of neurological
analysis to address a number of the major questions that have
arisen in the study of autism. The answers they present have
important implications for the direction of future autism research,
diagnosis, and treatment. What are the neurological signs and
symptoms of autism? The latest information is presented here in an
in-depth discussion of epilepsy, cranial circumference, changes in
muscle tone, stereotypies, and mutism found in children with
autism. In addition, a template is provided for practitioners to
follow when conducting neurological examinations of a child with
autism. What are the best options for the treatment of autism? The
current medical, educational, and alternative therapies are
thoroughly reviewed and evaluated. Is autism reversible? The
question is explored for syndromic autism, where diseases may have
a transient autistic phase, and reviewed in detail for nonsyndromic
autism.
Is autism primarily a single disease, as originally described by
Leo Kanner? Research presented here suggests that autism is,
instead, a syndrome involving many disease entities. Has the
incidence of autism been increasing in recent years? A
sophisticated, historical review of autisms prevalence rates
suggests that it has never been rare. What is the relationship
between autism and Asperger syndrome? The latest evidence presented
here sheds light on the degree to which both syndromes share more
than clinical characteristics; they also have some similar findings
in imaging, neuropathological, and genetic studies. Which
components of the brains neural networks need to be impaired to
cause the appearance of autistic symptoms? Although there are many
candidate regions, dysfunction of the cerebellum and its circuits
is noted to be of great interest. Student and professional
researchers, practitioners, and parents will find this book to be a
valuable resource for both the latest information from
basic-science research and its application to the diagnosis and
treatment of autism.
" This book] includes up-to-date genetic evidence, underlining the
complexities of genetic/environmental influences...I recommend this
easy and informative read." -European Journal of Pediatric
Neurology
..".authoritative." -The Lancet Neurology
"Coleman's new book is an absolute must-read for anyone interested
in the progress made in understanding the causes of autism. The
field owes her a tribute worthy of someone who has transformed an
area of neuroscience." -Simon Baron-Cohen in Nature Neuroscience
" I]nformative and comprehensive in its treatment of the
neurologic basis of autism...well written and easy to
understand...the contributing authors have done an excellent job of
making complex medical concepts understandable to all. The glossary
at the end of the book is extremely helpful in this regard. The
book is well referenced, provides helpful tables throughout, and
includes a summary of relevant points at the end of each
chapter.The authors are to be commended for presenting a very
balanced view of current knowledge; they also indicate what we do
not yet understand about brain functioning in autism and provide an
important road map for ongoing exploration." -Marshalyn
Yeargin-Allsopp in The New England Journal of Medicine
"At last it is recognised that developmental neurology is the
appropriate context in which to explain autism. The authors of this
volume, all pioneers in the field, consider new ideas on autism in
this context. They succeed in making surprising and illuminating
comparisons between autism and neurological disorders whose origin
is already known. This work is a significant step towards
understanding the causes of autistic disorders."-Uta Frith,
Institute of Cognitive Neuroscience and Department of Psychology,
University College London
"When and if the secret of autism is teased from the myriad
disease states that exhibit the syndrome, it will be through
efforts such as are represented in this volume. Dr. Coleman has
'picked the brains' of recognized experts from neurology and
related sciences, and has assembled a wealth of up-to-date and
meticulously referenced information regarding both those diseases
and the core symptoms of autism." -Peter B. Rosenberger,
Massachusetts General Hospital
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