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Testicular Autoimmunity - A Cause of Male Infertility (Hardcover, 1st ed. 2017)
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Testicular Autoimmunity - A Cause of Male Infertility (Hardcover, 1st ed. 2017)
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This book addresses various aspects of testicular autoimmunity. It
has long been suspected that testicular autoimmunity could be one
of the causes of idiopathic male infertility. However, it is very
difficult to estimate the incidence of testicular autoimmunity in
men, as most male patients first realize they are infertile when
they start trying to conceive a child, and there is a possibility
that their testes may already exhibit the end stage of testicular
autoimmunity, in which lymphocytic inflammation and immunoglobulin
deposition in their testes subsided long ago and only the
spermatogenic disorder remains. Therefore, autopsy or biopsy for
testicular tissues in men before the end stage of testicular
autoimmunity and investigations using testicular autoimmunity model
animals are needed to determine the epidemiology of testicular
autoimmunity. Accordingly, the book discusses "the immunological
fragility of testis" with regard to male infertility, reviewing
autopsy data in men and presenting experimental data using murine
models of autoimmune orchitis that has been induced by immunizing
with viable syngeneic testicular germ cells alone. Testicular
autoimmunity in animals is also discussed. In summary, the book
provides a wealth of valuable information, not only for researchers
who are interested in immunologic male infertility, but also for
clinical professionals who treat these patients at hospitals.
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