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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology

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mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardcover, 1st ed. 2016) Loot Price: R2,521
Discovery Miles 25 210
You Save: R261 (9%)
mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardcover, 1st ed. 2016): Monica Mita, Alain Mita, Eric Keith...

mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardcover, 1st ed. 2016)

Monica Mita, Alain Mita, Eric Keith Rowinsky

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List price R2,782 Loot Price R2,521 Discovery Miles 25 210 | Repayment Terms: R234 pm x 12* You Save R261 (9%)

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Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small- molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation. This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs.

General

Imprint: Springer Editions
Country of origin: France
Release date: November 2015
First published: 2016
Editors: Monica Mita • Alain Mita • Eric Keith Rowinsky
Dimensions: 235 x 155 x 18mm (L x W x T)
Format: Hardcover
Pages: 300
Edition: 1st ed. 2016
ISBN-13: 978-2-8178-0491-0
Categories: Books > Medicine > Clinical & internal medicine
Books > Medicine > Other branches of medicine
Books > Medicine > Clinical & internal medicine > Diseases & disorders
Books > Medicine > Other branches of medicine > Pharmacology
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
Books > Medicine > Other branches of medicine > Pharmacology > General
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
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LSN: 2-8178-0491-0
Barcode: 9782817804910

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