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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardcover, 1st ed. 2016)
Loot Price: R3,505
Discovery Miles 35 050
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mTOR Inhibition for Cancer Therapy: Past, Present and Future (Hardcover, 1st ed. 2016)
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Over the last 10 years, inhibitors of mTOR have emerged as a major
class of anticancer drugs. Two rapamycin analogs are currently
approved for the treatment of renal cell carcinoma, and it is
estimated that a variety of other tumor types could benefit from
mTOR inhibition, with numerous clinical trials (including pivotal
registration trials) already underway. Second-generation small-
molecule inhibitors of the pathway have also shown promise in terms
of their superior tolerability and efficacy and are undergoing
extensive clinical evaluation, with an estimated 30+ compounds
currently under evaluation. This book describes the challenges
involved in developing mTOR inhibitors for cancer treatment,
starting with an in-depth examination of their molecular mechanism
of action, with emphasis on the class side-effects, efficacy and
mechanisms of resistance, as well as on promising novel directions
for their development, including novel compounds and rational
combinations with other anti-neoplastic drugs.
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