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Circadian Clock - Regulations, Genetic and External Factors (Paperback)
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Circadian Clock - Regulations, Genetic and External Factors (Paperback)
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In this collection, the authors review temporal control of tissue
homeostasis and repair by the circadian system. The molecular
regulation of circadian timing has been well-characterized in
several species as a highly conserved transcriptional feedback loop
that maintains roughly 24-hour cellular periodicity. A current
challenge is determining how the outputs of the master clock affect
peripheral oscillators and numerous biological processes. A
subsequent study seeks a more detailed understanding of the
physiology and molecular mechanism underlying circadian changes in
the plasma of glucose, which might allow for the identification of
novel targets for the developing therapeutic approached to the
diabetes and obesity diseases. Procambarus acanthophorus, a
burrower crayfish, follows a nocturnal circadian rhythm due to the
way it spends long periods of time building tunnels to reach the
water table during the dry season. Therefore, it follows that this
species must have a close relationship with soil. The authors
suggest that soil might be an ecological factor with high perceived
value, influencing ecological aspects, and physiological functions
such as growth, reproduction, and organization of the circadian
system. The genes involved in the maintenance of circadian rhythm
and its impact on the immunological system are described as
disruption of the circadian rhythm leads to significant alterations
of the organism and is associated with several biological
responses. In the concluding review, some of the most useful
characteristics of zebrafish for studying the molecular, cellular,
and behavioral aspects of the circadian clock system are described.
Zebrafish have been established as an attractive vertebrate model
for the examination of light signaling pathways and their impact on
the cellular clock because zebrafish cellular clocks have an
unusual attribute of being directly light responsive. Additionally,
the molecular components of the mammalian and zebrafish cellular
clocks are highly similar.
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