The mediastinum is a hollow space within the thoracic cavity that
may give rise to a wide spectrum of tumoral conditions from the
benign to the intermediate to the highly malignant neoplasms. In
addition, other inflammatory and infectious conditions may also
arise in this space, which renders the practice of mediastinal
pathology, almost a general surgical pathology practice. However,
there are numerous mediastinal conditions that are important not
only for diagnosis but also for treatment and clinical outcome. Due
to the unusual location and because of the complexity of the tumors
occurring in the mediastinum, there are only a few experts in this
particular anatomic area. In fact, there are no more than 3-4
individuals worldwide with enough experience to properly diagnose,
classify, and make treatment suggestions when these tumors arise in
the mediastinum. More recent developments in tumor diagnosis and
classification have created a vacuum in the general pathologist who
often is confronted with this pathology and becomes uneasy about
the specifics. For instance, recent developments in tumor pathology
have led to the classification and staging of mediastinal tumors in
more innovative ways that are in need of proper highlighting.
Needless to say, even though there are a few publications on
mediastinal pathology, the books are either obsolete or incomplete,
in addition of providing superficial knowledge. Unfortunately and
with all due respect to the authors of those publications, neither
of those books is written by experts in the area. Rather the books
were written out of the lack of information in mediastinal
pathology. Even the World Health Organization (WHO) publication,
which is truly more on lung and pleural neoplasms, has inserted in
its contents a portion of mediastinal tumors, such portion not only
is superficial and incomplete but also at least highly
controversial if not flat out incorrect. . This text's goal is to
present comprehensive and up to date information of the diverse
pathology that can be encountered in the mediastinal compartment.
The book will be divided in 11 different chapters based on the
lineage of the diverse tumors that occur in the mediastinum, i.e.
epithelial, neuroendocrine, lymphoid, etc (see table of contents).
In addition, two separate chapters will be included -one on the
radiological aspects and the others on the surgical approach to the
different mediastinal tumors., bringing a total of 13 chapters. In
the pathology section, the book will include current staging and
classification systems of the different tumors. In addition, it
will address the most current criteria for diagnosis and the
differential diagnosis. Although the emphasis of the book is on
diagnostic surgical pathology, every chapter will include the use
of immunohistochemical techniques, electron microscopy, and
molecular biology when necessary. The book will be extensively
illustrated so that the reader will benefit of the different
histomorphology of mediastinal tumors. Because of the nature of
this specific anatomic area and the need to develop a standard
text, Mediastinal Pathology should be of high interest to general
surgical pathologists, thoracic pathologists in particular as well
as thoracic surgeons, oncologists, and radiologists. Needless to
say, this book will be of interest to pathology residents and
fellows as well as to those seeking more in depth knowledge of
thoracic - mediastinal pathology.
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