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Junk DNA - A Journey Through the Dark Matter of the Genome (Hardcover)
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Junk DNA - A Journey Through the Dark Matter of the Genome (Hardcover)
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For decades after the identification of the structure of DNA,
scientists focused only on genes, the regions of the genome that
contain codes for the production of proteins. Other regions that
make up 98 percent of the human genome were dismissed as "junk,"
sequences that serve no purpose. But researchers have recently
discovered variations and modulations in this junk DNA that are
involved with a number of intractable diseases. Our increasing
knowledge of junk DNA has led to innovative research and treatment
approaches that may finally ameliorate some of these conditions.
Junk DNA can play vital and unanticipated roles in the control of
gene expression, from fine-tuning individual genes to switching off
entire chromosomes. These functions have forced scientists to
revisit the very meaning of the word "gene" and have engendered a
spirited scientific battle over whether or not this genomic
"nonsense" is the source of human biological complexity. Drawing on
her experience with leading scientific investigators in Europe and
North America, Nessa Carey provides a clear and compelling
introduction to junk DNA and its critical involvement in phenomena
as diverse as genetic diseases, viral infections, sex determination
in mammals, and evolution. We are only now unlocking the secrets of
junk DNA, and Nessa Carey's book is an essential resource for
navigating the history and controversies of this fast-growing,
hotly disputed field.
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