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Genetics of Human Infertility (Hardcover)
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Genetics of Human Infertility (Hardcover)
Series: Monographs in Human Genetics, 21
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Infertility affects more than one in ten couples worldwide and is
related to highly heterogeneous pathologies sometimes only
discernible in the germ line. Its complex etiology often, but not
always, includes genetic factors besides anatomical defects,
immunological interference, and environmental aspects. Nearly 30%
of infertility cases are probably caused only by genetic defects.
Thereby experimental animal knockout models convincingly show that
infertility can be caused by single or multiple gene defects.
Translating those basic research ?ndings into clinical studies is
challenging, leaving genetic causes for the vast majority of
infertility patients unexplained. Nevertheless, a large number of
candidate genes have been revealed by sophisticated molecular
methods. This book provides a comprehensive overview on the subject
of infertility written by the leading authorities in this field. It
covers topics including basic biological, cytological, and
molecular studies, as well as common and uncommon syndromes. It is
a must-read for human geneticists, endocrinologists,
epidemiologists, zoologists, and counsellors in human genetics,
infertility, and assisted reproduction.
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