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Molecular Mechanisms of Microbial Evolution (Hardcover, 1st ed. 2018)
Loot Price: R6,490
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Molecular Mechanisms of Microbial Evolution (Hardcover, 1st ed. 2018)
Series: Grand Challenges in Biology and Biotechnology
Expected to ship within 10 - 15 working days
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One of the most profound paradigms that have transformed our
understanding about life over the last decades was the
acknowledgement that microorganisms play a central role in shaping
the past and present environments on Earth and the nature of all
life forms. Each organism is the product of its history and all
extant life traces back to common ancestors, which were
microorganisms. Nowadays, microorganisms represent the vast
majority of biodiversity on Earth and have survived nearly 4
billion years of evolutionary change. Microbial evolution occurred
and continues to take place in a great variety of environmental
conditions. However, we still know little about the processes of
evolution as applied to microorganisms and microbial populations.
In addition, the molecular mechanisms by which microorganisms
communicate/interact with each other and with multicellular
organisms remains poorly understood. Such patterns of microbe-host
interaction are essential to understand the evolution of microbial
symbiosis and pathogenesis.Recent advances in DNA sequencing,
high-throughput technologies, and genetic manipulation systems have
enabled studies that directly characterize the molecular and
genomic bases of evolution, producing data that are making us
change our view of the microbial world. The notion that mutations
in the coding regions of genomes are, in combination with selective
forces, the main contributors to biodiversity needs to be
re-examined as evidence accumulates, indicating that many
non-coding regions that contain regulatory signals show a high rate
of variation even among closely related organisms. Comparative
analyses of an increasing number of closely related microbial
genomes have yielded exciting insight into the sources of microbial
genome variability with respect to gene content, gene order and
evolution of genes with unknown functions. Furthermore, laboratory
studies (i.e. experimental microbial evolution) are providing
fundamental biological insight through direct observation of the
evolution process. They not only enable testing evolutionary theory
and principles, but also have applications to metabolic engineering
and human health. Overall, these studies ranging from viruses to
Bacteria to microbial Eukaryotes are illuminating the mechanisms of
evolution at a resolution that Darwin, Delbruck and Dobzhansky
could barely have imagined. Consequently, it is timely to review
and highlight the progress so far as well as discuss what remains
unknown and requires future research. This book explores the
current state of knowledge on the molecular mechanisms of microbial
evolution with a collection of papers written by authors who are
leading experts in the field.
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