Nerve growth factor (NGF) has a key role not only in the
development of sensory and autonomic neurons, but also in the
processes of nociception. Several central and peripheral mechanisms
have been postulated as the basis of effects of NGF in nociceptive
pathways. It has been implicated both in inflammatory and
neuropathic pain mechanisms and strategies against NGF, its
receptors, and down-stream intracellular signalling activated by
this neurotrophin (NT) have been proposed for the treatment of
these pathological conditions. This book examines recent evidence
of the involvement of NGF in painful diseases and suggests the
potential usefulness of anti-NGF strategies as novel analgesics for
these disabling pathological conditions.
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