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Developments in T Cell Based Cancer Immunotherapies (Hardcover, 1st ed. 2015)
Loot Price: R5,465
Discovery Miles 54 650
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Developments in T Cell Based Cancer Immunotherapies (Hardcover, 1st ed. 2015)
Series: Cancer Drug Discovery and Development
Expected to ship within 12 - 17 working days
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This volume illustrates the salient aspects of cancer biology
relevant to the successful implementation of immunotherapy. Topics
include enhancement of antigen-specific immune responses by
anti-cancer vaccines, modulation of the function of T cells within
the tumor microenvironment, and the effects of genetic, epigenetic,
developmental, and environmental determinants on T cell function.
Other topics covered include the ex vivo expansion of T or other
immune cells and their genetic modification or reprogramming to
increase their ability to survive and expand when adoptively
transferred back to the patients. Specific attention is devoted to
the genetic manipulation of T cells through the introduction of
re-directed T cell receptors, chimeric antibody receptors, and
other genetic manipulation aimed at improving their effectiveness
as anti-cancer agents. Furthermore, the revolutionary role of
checkpoint inhibitors and their potential in combination with other
immunotherapeutic approaches or with standard chemo and radiation
therapy are extensively discussed.
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