The NSAIDs have known to cause serious problems such as gastric
ulceration, bleeding and renal disorders on long term medication.
These severe side effects are partially due to their nonselectivity
towards to COX-2 enzyme. Hence, newer, selective COX-2 enzyme
inhibitors have been developed to overcome the toxicity problems.
Recently, Rofecoxib and Celecoxib were withdrawn due to cardiac
toxicity.1,2-disubstituted five-membered heterocyclic compounds
have shown selectivity towards COX-2 inhibition. But, the toxicity
reports of drugs like Rofecoxib and Celecoxib in this category
prompted us to synthesize 1,2-diaryl diazepines (E) and their
derivatives as, survey of literature indicated the diazepine
heterocyclic system to have anti-inflammatory activity.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
United States |
Release date: |
February 2013 |
First published: |
February 2013 |
Authors: |
Patel Chirag J.
|
Dimensions: |
229 x 152 x 4mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
68 |
ISBN-13: |
978-3-659-33786-4 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
|
LSN: |
3-659-33786-2 |
Barcode: |
9783659337864 |
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