Design and Synthesis of 1,4-Diazepines as Selective Cox-II Inhibitors (Paperback)

The NSAIDs have known to cause serious problems such as gastric ulceration, bleeding and renal disorders on long term medication. These severe side effects are partially due to their nonselectivity towards to COX-2 enzyme. Hence, newer, selective COX-2 enzyme inhibitors have been developed to overcome the toxicity problems. Recently, Rofecoxib and Celecoxib were withdrawn due to cardiac toxicity.1,2-disubstituted five-membered heterocyclic compounds have shown selectivity towards COX-2 inhibition. But, the toxicity reports of drugs like Rofecoxib and Celecoxib in this category prompted us to synthesize 1,2-diaryl diazepines (E) and their derivatives as, survey of literature indicated the diazepine heterocyclic system to have anti-inflammatory activity.

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	United States
Release date:	February 2013
First published:	February 2013
Authors:	Patel Chirag J.
Dimensions:	229 x 152 x 4mm (L x W x T)
Format:	Paperback - Trade
Pages:	68
ISBN-13:	978-3-659-33786-4
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	3-659-33786-2
Barcode:	9783659337864

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