Sustained release drug system is any drug or dosage form
modification that prolongs the therapeutic activity of the drug.
Ideally a sustained release oral dosage form is designed to release
rapidly some predetermined fraction of the total dose in to GI
tract. This fraction (loading dose) is an amount of drug, which
will produce the desired pharmacological response as promptly as
possible and the remaining fraction of the total dose (maintenance
dose) is then release at a constant rate. The rate of the drug
absorption from the entire maintenance dose into the body should
equal to the rate of the drug removal from the body by all the
processes over the time for which the desired intensity of
pharmacological response is required. We sincerely hope that this
book will helpful to student as well as industry and academic
professionals involved in pharmaceutical and other related science.
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