One of the few books to cover all aspects of cyclin-dependent
kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as
Anti-tumor Agents provides an overview of CDKs as molecular and
functional entities, their involvement in different disease
processes, and their potential for pharmacological modulation. With
contributions from the top international researchers in the field,
the book takes a contemporary approach to study the importance of
rational drug design and knowledge-based therapeutics in relation
to CDKs.
The first two sections of the book discuss the integration of
cell cycle control pathways, opportunities for targeting, targets
of inhibitors, and the evaluation of CDK inhibitors, exploring
topics such as the "in vivo "function of CDKs in normal
homeostasisand tumor development and the structural biology of
CDKs. The third section examines the design, development, and
chemistry of small molecule CDK inhibitors, with discussions
ranging from the early-stage discovery ofnew chemical entities with
a capacity to inhibit CDKs to late-stage compounds in clinical
development. The final section assesses the current status of CDK
inhibitors in clinical trials, the therapeutic deployment
challenges of small molecule inhibitors, and the future development
of CDK inhibitors as anticancer agents.
The field of drug development is at a critical point in terms of
understanding the availability, advantages, and drawbacks of CDKs
as therapeutic targets for small molecules. Providing the most
up-to-date, in-depth coverage available in a single volume,
Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents surveys
the success of the agents developed thus far, the possibility of
newroutes to more selective inhibitors, and the growing
appreciation of critical, therapeutic issues.
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