The Male Role in Pregnancy Loss and Embryo Implantation Failure (Hardcover, 1st ed. 2015)

Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Advances in Experimental Medicine and Biology, 868
Release date:	July 2015
First published:	2015
Editors:	Richard Bronson
Dimensions:	235 x 155 x 19mm (L x W x T)
Format:	Hardcover - Cloth over boards
Pages:	228
Edition:	1st ed. 2015
ISBN-13:	978-3-319-18880-5
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology Books > Medicine > Pre-clinical medicine: basic sciences > Human reproduction, growth & development > Reproductive medicine > General
LSN:	3-319-18880-1
Barcode:	9783319188805

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