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Circulating Tumor Cells in Breast Cancer Metastatic Disease (Hardcover, 1st ed. 2020)
Loot Price: R2,941
Discovery Miles 29 410
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Circulating Tumor Cells in Breast Cancer Metastatic Disease (Hardcover, 1st ed. 2020)
Series: Advances in Experimental Medicine and Biology, 1220
Expected to ship within 10 - 15 working days
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This book is aimed to summarise the key aspects of the role of
circulating tumour cells (CTCs) in breast cancer, with special
attention to their contribution to tumour progression and
establishment of metastatic disease. We aim to give a clear
overview of the knowledge about CTCs, framed in the context of
breast cancer, by analysing basic and clinical research carried out
so far. In a broader sense, we will address what are the main
clinical needs of this disease based on its molecular heterogeneity
(subtypes) and lay out the knowledge and understanding that CTCs
are giving about it and how they are contributing and can still
improve the better monitoring and management of breast cancer
patients. We will discuss the evidences of the use of CTCs as a
tool to monitor cancer progression and therapy response, based on
the prognostic and predictive value they have, as well as a tool to
unravel mechanisms of resistance to therapy and to identify new
biomarkers allowing to predict therapy success. Moreover, we will
analyse the main aspects of ongoing clinical trials and how they
can contribute to determine the clinical utility of CTCs as a
breast cancer biomarker. We will also touch upon general knowledge
or basic notions of the biology of the metastatic process in
epithelial cancers, in order to understand the origin and biology
of CTCs. In this sense, we will pay special attention to EMT
(epithelial to mesenchymal transition), dormancy and minimal
residual disease, three key aspects that determine the outcome of
the disease. We will also cover general aspects on the isolation
and characterization techniques applies to the study of CTCs, and
also the possibilities that the study of CTCs, as a biomarker with
biological function, is opening in terms of understanding the
biology of metastatic cells and the identification of therapeutic
targets based on the functional and molecular characterization of
CTCs. Lastly, we will try to foresee the future of CTCs in terms of
clinical application and implementation in the clinical routine.
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