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Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction - UNESCO (Paperback, Softcover reprint of the original 1st ed. 1992)
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Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction - UNESCO (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Molecular and Cell Biology Updates
Expected to ship within 10 - 15 working days
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Adenine Nucleotides play a major role in cellular metabolism and
functions, serving as high-potential phosphate transfer compounds
in energy metabolism and as substrates and co-factors for proteins
involved in signal transduction. During the last few years definite
advancement has been made in elucidating the molecular and genetic
aspects of the enzyme involved in oxidative phosphorylation, the
so-called FoFl H~-ATP synthase. Non-invasive NMR technologies have
been developed to monitor in vivo the energy level of tissues based
on determination of the concentrations of adenine nucleotides,
phosphate and phosphate esters. Thus it became clear that the
capacity of oxidative phosphorylation adapts itself to the ATP
demand which changes continuously with the physiological state in
various tissues. This is achieved by regulation of the enzyme
activity as well as by regulation of its biogenesis. The reversible
phosphorylation of proteins is re- cognised as a major regulatory
mechanism in eukaryotic as well as in prokaryotic cells for
cellular signal transduction and control of gene expression, cell
growth, differentation and oncogenesis. The same applies to the
role played by cAMP. A further topic of growing interest concerns
the discovery of the ATP binding cassette (ABC) superfamily of
transport proteins which includes systems of primary importance in
medicine such as the multi-drug resistance P glycoprotein, the
cystic fibrosis transmembrane conductance regulator (CFTR) and the
70 kd peroxisomal membrane protein. Finally, much attention is
being devoted in many laboratories to the molecular structure and
role of ATP- modulated channels.
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