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Proteases in Human Diseases (Hardcover, 1st ed. 2017)
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Proteases in Human Diseases (Hardcover, 1st ed. 2017)
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This book bridges the gap between fundamental research and
biomedical and pharmacological applications on proteases. It
represents a comprehensive overview of the multifaceted field of
proteases in cellular environment and highlights the recently
elucidated functions of complex proteolytic systems in different
diseases. Several established investigators have elucidated the
crucial role of proteases in biological processes, including how
proteolytic function and regulation can be combined to develop new
strategies of therapeutic interventions. Proteases form one of the
largest and most diverse families of enzymes known. It is now clear
that proteases are involved in every aspect of life functions of an
organism. Under physiological conditions, proteases are regulated
by their endogenous inhibitors; however, when the activity of
proteases is not regulated appropriately, disease processes can
result in. So, there is absolute need for a stringent control of
proteolytic activities in cells and tissues. Dysregulation of
proteases may cause derangement of cellular signalling network
resulting in different pathophysiological conditions such as
vascular remodelling, atherosclerotic plaque progression, ulcer and
rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor
progression and inflammation. Additionally, many infective
microorganisms require proteases for replication or use proteases
as virulence factors, which have facilitated the development of
protease-targeted therapies for a variety of parasitic diseases.
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