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Proteases in Physiology and Pathology (Hardcover, 1st ed. 2017)
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Proteases in Physiology and Pathology (Hardcover, 1st ed. 2017)
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Using a multidisciplinary approach, this book describes the
biochemical mechanisms associated with dysregulation of proteases
and the resulting pathophysiological consequences. It highlights
the role and regulation of different types of proteases as well as
their synthetic and endogenous inhibitors. The role of proteases
was initially thought to be limited to general metabolic digestion.
However, we now know that the role of protein breakdown is much
more complex, and proteases have multiple functions: they are
coupled to turnover and can affect protein composition, function
and synthesis. In addition to eliminating abnormal proteins,
breakdown has many modulatory functions, including activating and
inactivating enzymes, modulating membrane function, altering
receptor channel properties, affecting transcription and cell
cycles and forming active peptides. The ubiquity of proteases in
nature makes them an important target for drug development. This
in-depth, comprehensive is a valuable resource for researchers
involved in identifying new targets for drug development. With its
multidisciplinary scope, it bridges the gap between fundamental and
translational research in the biomedical and pharmaceutical
industries, making it thought-provoking reading for scientists in
the field.
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