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Targeting the Broadly Pathogenic Kynurenine Pathway (Hardcover, 1st ed. 2015)
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Targeting the Broadly Pathogenic Kynurenine Pathway (Hardcover, 1st ed. 2015)
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Tryptophan metabolism via kynurenine pathway plays a critical role
in both health and a variety of human diseases. This book
highlights the known associations between kynurenine pathway and
various disease states, as well as examines the current status of
drug development and clinical trials of compounds known to alter
tryptophan metabolism. The research plays a critical role in
molecular targeted therapies directed at altering the kynurenine
pathway of tryptophan metabolism. The initial and rate-limiting
step of tryptophan metabolism is mediated by one of two enzymes,
tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but
also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host
of tissues in response to immune activation). Targeting the enzymes
IDO and TDO, as well as other downstream effectors would therefore
be likely to generate novel treatment options that would be helpful
in a wide variety of clinical settings. This book provides a unique
bridge between basic mechanistic understanding of the role of the
kynurenine pathway with translational applications and clinical
relevance. It will explore the indications that tryptophan
metabolism is a potential biomarker of disease activity, can
contribute to local and possibly systemic immune suppression in
cancer, and is an attractive target for which a variety of
inhibitors are readily available.
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