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Biomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges (Hardcover, 1st ed. 2016)
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Biomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges (Hardcover, 1st ed. 2016)
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This book is oriented towards post-graduates and researchers with
interest in proteomics and its applications in clinical biomarker
discovery pipeline. Biomarker discovery has long been the research
focus of many life scientists globally. However, the pipeline
starting from discovery to validation to regulation as a diagnostic
or therapeutic molecule follows a complex trajectory. This book
aims to provide an in-depth synopsis on each of these developmental
phases attendant to biomarker "life cycle" with emphasis on the
emerging and significant role of proteomics. The book begins with a
perspective on the role of biorepositories and need for biobanking
practices in the developing world. The next chapter focuses on
disease heterogeneity in context to geographical bias towards
susceptibility to the disease and the role of multi-omics
techniques to devise disruptive innovations towards biomarker
discovery. Chapter 3 focuses on various omics-based platforms that
are currently being used for biomarker discovery, their principles
and workflow. Mass spectrometry is emerging as a powerful
technology for discovery based studies and targeted validation.
Chapter 4 aims at providing a glimpse of the basic workflow and
considerations in mass spectrometry based studies. Rapid and aptly
targeted research funding has often been deemed as one of the
decisive factors enabling excellent science and path breaking
innovations. With the need for sophistication required in
multi-omics research, Chapter 5 focuses on innovative funding
strategies such as crowdfunding and Angel philanthropy. Chapter 6
provides the latest advances in education innovation, the premise
and reality of bioeconomy especially in a specific context of the
developing world, not to mention the new concept of "social
innovation" to link biomarkers with socially responsible and
sustainable applications. Chapter 7, in ways similar to biomarkers,
discusses the biosimilars as a field that has received much focus
and prominence recently due to their immense potential in clinical
and pharmaceutical innovation literatures. The broader goal
post-biomarker discovery is to translate their use in clinics.
However, the road from bench-to-bed side is arduous and complex
that is subject to oversight from various national and
international regulatory bodies. Chapter 8 underscores these
regulatory science considerations and provides a concise overview
on intellectual property rights in biomarker discovery. Thus, this
book contributed by eminent biomarker scientists, clinicians,
translational researchers and social scientists holistically covers
the various facets of the biomarker discovery journey from "cell to
society" in developing world. The lessons learned and highlighted
here are of interest to the life sciences community in a global and
interdependent world.
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