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Cardiac Resynchronization Therapy - From Epigenetic to Social Networks (Hardcover)
Loot Price: R4,374
Discovery Miles 43 740
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Cardiac Resynchronization Therapy - From Epigenetic to Social Networks (Hardcover)
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Over the last few decades, cardiac resynchronization therapy (CRT)
has been introduced as a choice treatment for heart failure (HF)
patients, refractory to maximal drug therapy and left bundle branch
block. Advanced heart failure is related to cardiac fibrosis,
hypertrophy and apoptosis, and CRT in 30% of patients is not able
to ameliorate cardiac performance and mechanical efficiency. This
clear loss of effect (CRT failure) is frustrating and leaves HF
patients in a steady and/or advanced, uncontrolled worsening state
of clinical symptoms and NYHA class. Several hypotheses have been
conducted to explain this loss of effect: investigating epigenetic
(microRNAs activation pattern), echocardiography (mechanical
cardiac dyssynchrony assessment), arrhythmias (atrial fibrillating
patients), left ventricle lead positioning (target wall and vessel)
and pacing modalities (bipolar vs multipolar), and epicardial
approaches (cardiac surgery) to reach the target ventricular wall.
The selection criteria, the implant technique and CRT monitoring
are relevant aspects of the CRT world in all its complexity. The
necessity to follow and characterize CRT recipients (responders vs
non responders), and the routine follow up with recent advancements
in technology (telemonitoring) may be an instrument to improve CRT
response entity and clinical outcomes. The creation of a social
platform (social networks) may represent a necessary and
evolutionary step to share individual experiences and to exchange
ideas about CRT recipients and experienced operators. The
opportunity to improve CRT responders percentage may represent a
gold standard and an attractive prospective in failing heart
patients CRT recipients. In this book, we have investigated these
aspects, hoping to provide to the reader the right reading tools in
the CRT world. Our message remains: To help people suffering from
cardiovascular diseases and to live better with their disease.
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