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Obesity, Type 2 Diabetes and the Adipose Organ - A Pictorial Atlas from Research to Clinical Applications (Hardcover, 2nd ed. 2018)
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Obesity, Type 2 Diabetes and the Adipose Organ - A Pictorial Atlas from Research to Clinical Applications (Hardcover, 2nd ed. 2018)
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This richly illustrated book provides a detailed description of the
gross anatomy, light microscopy, immunohistochemistry, and electron
microscopy of the adipose organ, which comprises subcutaneous and
visceral fat depots. Findings in mice of differing genetic
backgrounds (obesity prone and resistant) and maintained in
standard and various physiologic and pathologic conditions are
presented. The latter conditions include chronic cold exposure,
warm exposure, fasting, pregnancy-lactation, and obesity. Features
of the fetal adipose organ are described in a separate chapter, and
results from transgenic mice are also presented when relevant. The
human adipose organ is addressed in several chapters that include
magnetic resonance and fetal findings. Most of the results
regarding the adipose organ anatomy in different physiologic
conditions are new, and the story of pink adipocytes (white-to-pink
transdifferentiation) is quite innovative. The concept of using
browning of the adipose organ as a therapeutic tool for obesity
must take into consideration the anatomic and morphologic aspects
described here, and the study of pink adipocytes could lead to a
better comprehension of breast cancer tumor biology. This book will
be of interest to all scientists who deal with obesity and related
disorders.
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