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Meiosis - Volume 1, Molecular and Genetic Methods (Hardcover, 2009 ed.)
Loot Price: R3,013
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Meiosis - Volume 1, Molecular and Genetic Methods (Hardcover, 2009 ed.)
Series: Methods in Molecular Biology, 557
Expected to ship within 10 - 15 working days
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Each generation in a sexually reproducing organism such as a fly or
a mouse passes through the bottleneck of meiosis, which is the
specialized cell division that gives rise to haploid reproductive
cells (sperm, eggs, spores, etc. ). The principal function of
meiosis is to reduce the genome complement by half, which is
accomplished through sequential execution of one round of DNA
replication followed by two rounds of chromosome segregation.
Within the extended prophase between DNA replication and the first
meiotic division in most organisms, homologous maternal and
paternal chromosomes pair with one another and undergo homologous
recombination, which establishes physical connections that link the
homologous chromosomes until the time they are separated at
anaphase I. Recombination also serves to increase genetic diversity
from one generation to the next by breaking up linkage groups. The
unique chromosome dynamics of meiosis have fascinated scientists
for well over a century, but in recent years there has been an
explosion of new information about how meiotic chromosomes pair,
recombine, and are segregated. Progress has been driven by advances
in three main areas: (1) genetic identification of
meiosis-defective mutants and cloning of the genes involved; (2)
development of direct physical assays for DNA intermediates and
products of recombination; and (3) increasingly sophisticated cy-
logical methods that describe chromosome behaviors and the spatial
and temporal patterns by which specific proteins associate with
meiotic chromosomes.
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