The mammalian genome is constantly challenged by exogenous and
endogenous threats. Although much is known about the mechanisms
that maintain genome integrity, little is known about the
applications of this knowledge to combat human disease. The past 20
years has witnessed extensive research and progress in this area
and scientists started to design new therapies harnessing
individual genetic differences among patients to combat
degenerative disorders and cancer. We summarize these advancements
and discuss perspectives for the future of personalized medicine.
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