This book provides comprehensive coverage of small fiber neuropathy
(SFN), from diagnosis to therapy. It focuses on nerve degeneration
and neuropathic pain, and their underlying pathology, physiology,
psychophysics, genetics and imaging. In particular, this book
describes and discusses the major advances in diagnostic techniques
for assessing SFN. These include skin biopsy, evoked potentials,
quantitative sensory testing and functional studies, as biomarkers
of SFN. SFN is a common peripheral nerve disorder, but was often
overlooked due to a lack of objective and specific diagnostic tests
for the assessment of small nerve fibers. These fibers mediate
thermal sensation, pain detection (nociception), and autonomic
regulation. Major symptoms of SFN include neuropathic pain,
impaired sensation and autonomic dysfunction. Neuropathic pain
poses a diagnostic challenge to clinicians, an essential step for
selecting appropriate treatment to relieve suffering. SFN
frequently develops in systemic diseases such as diabetes mellitus,
following chemotherapy, infections etc., or presents as a major
feature of various genetic neuropathies (e.g. channelopathy and
familial amyloidosis). In addition to describing these conditions
which lead to SFN, this book also describes related syndromes of
neurodegeneration and pain, including fibromyalgia, visceral pain
and hypersensitivity. This definitive book covers both clinical
aspects and research progress, which provides in-depth and
up-to-date information on SFN. It would be immensely useful for
clinicians, neurologists, neuroscientists, diabetologists, and pain
specialists. Dr. Sung-Tsang Hsieh is a professor at Department of
Neurology and Institute of Anatomy and Cell Biology, College of
Medicine, National Taiwan University, Taiwan. He is also the
associate dean of College of Medicine, National Taiwan University,
Taiwan. Dr. Praveen Anand is a professor at Department of Clinical
Neurology and head of Centre for Clinical Translation, Hammersmith
Hospital, UK. Dr. Christopher Gibbons is an associate professor of
Neurology, Harvard Medical School, Beth Israel Deaconess Medical
Center, USA. Dr. Claudia Sommer is a professor of Neurology at the
Department of Neurology, Wurzburg University Hospital, Germany.
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