Huntington's disease, chorea or disorder (HD) is an incurable
neurodegenerative genetic disorder, which affects muscle
co-ordination and some cognitive functions, typically becoming
noticeable in middle age. It is the most common genetic cause of
abnormal involuntary writhing movements called chorea and is much
more common in people of Western European descent than in those
from Asia or Africa. The disease is caused by a dominant mutation
on either of the two copies of a gene called Huntington. This book
gathers and presents current research in the study of Huntington's
Disease including the outlining effects of mutant htt in the
nucleus and cytoplasm and the role of cell-cell interactions in
Huntington's Disease pathology, as well as a review of the role of
Huntington (HTT) interacting proteins.
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