Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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DNA Conjugates and Sensors (Hardcover)
Loot Price: R5,271
Discovery Miles 52 710
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DNA Conjugates and Sensors (Hardcover)
Series: RSC Biomolecular Sciences, Volume 26
Expected to ship within 12 - 17 working days
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Applications of nucleic acids have developed recently to provide
solutions for biosensors, diagnostic tools and as platforms for the
assembly of complex structures. These developments have been
possible as their base sequence can be used to assemble precise
structures following simple and predictable rules. Self-assembled
DNA can then be amplified using polymerase chain reaction (PCR) and
this ultimately enables the preparation of synthetic nucleic acids.
Their use as molecular tools or DNA-conjugates has recently been
enhanced by the addition of other groups including enzymes,
fluorophores and small molecules. Written by leaders in the field,
this volume describes the preparation and application of these
DNA-conjugates. Several have been used as sensors (aptamers,
riboswitches and nanostructures) based on the ability of nucleic
acids to adopt specific structures in the presence of ligands,
whilst others link reporter groups such as proteins or fluorophores
to RNA or DNA for detection, single molecule studies, and
increasing the sensitivity of PCR. The book is relevant to
researchers in areas related to analytical chemistry, chemical
biology, medicinal chemistry, molecular pharmacology, and
structural and molecular biology.
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