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Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs (Hardcover, 1st ed. 2016)
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Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs (Hardcover, 1st ed. 2016)
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Clinically-focussed, with easily accessible tables and chapter
summaries suitable for clinicians and researchers, this
comprehensive book provides a systematic, critical evaluation of
the current literature. An updated clinical decision-making
algorithm specifically tailored to the antiretroviral drugs is also
provided. The identified interactions are interpreted in the
context of known mechanisms derived from clinical, preclinical, and
in vitro data. The clinical relevance of the interactions is
systematically evaluated and gaps in literature discussed in the
context of potential future experiments. In addition to the
comprehensive summary of pharmacokinetic and pharmacodynamic drug
interactions associated with WHO-recommended antiretroviral drugs
on the market today (i.e. nucleotide reverse-transcriptase
inhibitors, non-nucleoside reverse-transcriptase inhibitors,
integrase inhibitors, and protease inhibitors), this book also
provides detailed section summaries on the epidemiology of HIV
infection, diagnosis and pharmacotherapy, basic pharmacology of the
individual antiretrovirals, pertinent pre-clinical and in vitro
molecular pharmacology, and in vitro drug interaction data
available in the literature today.
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