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RNA Exosome (Hardcover, 2010 ed.)
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RNA Exosome (Hardcover, 2010 ed.)
Series: Advances in Experimental Medicine and Biology, 702
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The diversity of RNAs inside living cells is amazing. We have known
of the more "classic" RNA species: mRNA, tRNA, rRNA, snRNA and
snoRNA for some time now, but in a steady stream new types of
molecules are being described as it is becoming clear that most of
the genomic information of cells ends up in RNA. To deal with the
enormous load of resulting RNA processing and degradation
reactions, cells need adequate and efficient molecular machines.
The RNA exosome is arising as a major facilitator to this effect.
Structural and functional data gathered over the last decade have
illustrated the biochemical importance of this multimeric complex
and its many co-factors, revealing its enormous regulatory power.
By gathering some of the most prominent researchers in the exosome
field, it is the aim of this volume to introduce this fascinating
protein complex as well as to give a timely and rich account of its
many functions. The exosome was discovered more than a decade ago
by Phil Mitchell and David Tollervey by its ability to trim the
3'end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account
they laid out the events surrounding this identification and the
subsequent birth of the research field. In the chapter by Kurt
Januszyk and Christopher Lima the structural organization of
eukaryotic exosomes and their evolutionary counterparts in bacteria
and archaea are discussed in large part through presentation of
structures.
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