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Myelodysplastic Syndromes - Diagnosis - Prognosis - Therapy (Hardcover, 1st ed. 2018)
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Myelodysplastic Syndromes - Diagnosis - Prognosis - Therapy (Hardcover, 1st ed. 2018)
Series: Hematologic Malignancies
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This book reviews the standard diagnostic and therapeutic
management of patients with myelodysplastic syndromes (MDS) and
examines ongoing research developments in the field. The importance
of appropriate prognostic stratification, taking into account
recent advances in understanding of the molecular pathogenesis of
MDS, is explained, and both established and novel treatment
approaches are discussed in depth. The coverage includes, for
example, the use of erythropoietic stimulating agents, iron
chelation therapy, the immunomodulator lenalidomide,
hypomethylating agents such as azacitidine, and allogeneic
hematopoietic stem cell transplantation. Myelodysplastic syndromes
are heterogeneous and complex hematologic disorders ranging from
indolent conditions to forms approaching the aggressiveness of
acute myeloid leukemia. The diversity of MDS gives rise to
challenges in diagnosis and clinical decision making, and the
highly variable clinical course necessitates a risk-adapted
treatment strategy and the application of disease-specific
therapies. Hematologists, oncologists, and other interested
clinicians will find this book to be an invaluable source of
information on diagnostic and prognostic evaluation and treatment
selection.
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