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Hyaluronic Acid - Preparation, Properties, Application in Biology and Medicine (Hardcover)
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Hyaluronic Acid - Preparation, Properties, Application in Biology and Medicine (Hardcover)
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Hyaluronic acid is an essential part of connective, epithelial and
neural tissues, and contributes to cell proliferation and
migration. It is used as a stimulating agent for collagen synthesis
and is a common ingredient in skin-care products, a multi-billion
dollar industry, as it is believed to be a key factor in fighting
the aging process. Hyaluronic Acid: Production, Properties,
Application in Biology and Medicine consists of six chapters
discussing the various issues of hyaluronic acid research. In
Chapter 1, a historical analysis recounts the discovery and
milestones of the research leading to the practical applications of
hyaluronan. Chapter 2 is dedicated to biological role of the
hyaluronic acid in nature, in particular in the human body. The
chapter starts from the phylogenesis of hyaluronic acid, then
describes hyaluronan functions in human ontogenesis and especially
the role which hyaluronan plays in extracellular matrix of the
different tissues. Chapter 3 describes the methods to manufacture
and purify hyaluronic acid, including the analytical means for
assessing quality of the finished product. Chapter 4 discusses the
structure and rheological properties of hyaluronic acid considering
effects on conformation and biological properties related to
molecular weight. In Chapter 5, the physical and chemical methods
for modifying the structure of hyaluronan are discussed including
cross-linking using bi-functional reagents, solid-phase
modification and effects of the combined action of high pressures
and shift deformation. The final chapter focuses on the products
derived from hyaluronic acid, including therapeutics composed of
modified hyaluronan conjugated to vitamins, amino acids and
oligo-peptides. The biological roles and medical applications of
this polysaccharide have been extensively studied and this book
provides a wealth of scientific data demonstrating the critical
role of hyaluronic acid and its promise as a multifaceted
bio-macromolecule. Approaching hyaluronic acid from multiple
angles, this book links relationships between its biological
functions, structure and physical chemical properties. It will be
an invaluable resource to researchers, both industrial and
academic, involved in all aspects of hyaluronan-based technologies.
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