Previous studies demonstrated that thiosemicarbazone iron chelator
possessed potent and selective anti-cancer activity. In this study,
the in vitro and in vivo anti-tumor efficacy and tolerability of
2-benzoylpyridine thiosemicarbazone (BpT) iron chelators were
examined. The BpT chelators were tested against human lung cancer
cells in vitro and tumor xenografts in mice. The toxicity of Bp44mT
and its effects on the expression of iron-regulated molecules
involved in growth and cell cycle control were investigated. The
results shown demonstrate the anti-tumor activity of the
orally-active Bp44mT chelator, which was well tolerated in vivo.
Furthermore, the cytotoxicity of thiosemicarbazones is likely to be
mediated, in part, through their redox activity and effects on
multiple thiol-containing systems. In terms of signal transduction,
iron chelation may influence the MAPK signaling pathways via the
thioredoxin-ASK1 signalosome. These results emphasize the
importance of redox-activity of thiosemicarbazone chelators.
Considering their potent anti-tumor activity, these investigations
facilitate the future development of promising thiosemicarbazone
iron chelators as anti-cancer agents.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
July 2011 |
First published: |
July 2011 |
Authors: |
W. Yu
• Des Richardson
|
Dimensions: |
229 x 152 x 13mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
220 |
ISBN-13: |
978-3-8443-8676-9 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-8443-8676-9 |
Barcode: |
9783844386769 |
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!