Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Principles of Cancer Treatment and Anticancer Drug Development (Hardcover, 1st ed. 2019)
Loot Price: R1,307
Discovery Miles 13 070
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Principles of Cancer Treatment and Anticancer Drug Development (Hardcover, 1st ed. 2019)
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This book explains how current medicines against cancer work and
how we find new ones. It provides an easy-to-understand overview of
current options to treat patients with cancer, which includes
Surgery, Radiation therapy, Chemotherapy, Targeted therapy and
Immunotherapy. The efficiency of all these treatments is limited by
the capacity of cancer cells to escape therapy. This book explains
the mechanisms of anti-cancer drug resistance and strategies to
overcome it. The discovery and development process of a new drug is
detailed beginning with the identification and validation of a
therapeutic target, the identification of an inhibitor of the
target and its subsequent preclinical and clinical development
until its approval by regulatory authorities. Particular emphasis
has been given to specific aspects of the development process
including lead generation and optimization, pharmacokinetics, ADME
analysis, pharmacodynamics, toxicity and efficacy assessment,
investigational new drug (IND) and new drug application (NDA) and
the design of clinical trial and their phases. The book covers many
aspects of modern personalized oncology and discusses economic
aspects of our current system of developing new medicines and its
impact on our societies and on future drug research. The author of
this book, Dr. Link counts with more than 20 years of experience in
biomedical research reflected in numerous publications, patents and
key note and plenary presentations at international conferences.
Interested readers, students and teachers should read this book as
it provides a unique way to learn/teach about basic concepts in
oncology and anti-cancer drug research.
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