Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Inflammation and Metastasis (Hardcover, 1st ed. 2016)
Loot Price: R4,529
Discovery Miles 45 290
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Inflammation and Metastasis (Hardcover, 1st ed. 2016)
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This book provides the latest information on cancer metastasis from
the standpoint of inflammation, especially innate immune reactions
caused by endogenous mediators but not exogenous pathogens, with
ideas on how to understand the complicated mechanisms of metastasis
as well as to interpret therapeutic targets. The book includes the
topic of the emerging roles of endogenous TLR4 ligands whose
functions are shared intriguingly by metastasis and
auto-inflammatory diseases such as rheumatoid arthritis. For
example, most cancer therapies established so far are effective
initially. However, they eventually face the great obstacles of
drug resistance, immune evasion, and metastatic progression. One of
the endogenous TLR4 ligands is thought to contribute to all three
processes. The most important features of the book are to explain a
concept of homeostatic inflammation, disturbance of which in the
lungs gives rise to the establishment of a pre-metastatic pulmonary
microenvironment based on primary tumor-mediated hijacking of the
innate immune defense system against respiratory infection. In
addition, structure-based thinking is another important feature of
this book. It is proposed that inflammation forms a functional
triangle with angiogenesis and coagulation, in the center of which
cancer is located. Given the proposal of precision medicine by
President Obama in the United States in 2015 and the recent success
of immune-modulator-based therapy, this book will appeal to
researchers in a variety of fields with the title of the book
connecting the worst disease (metastasis) and the most fundamental
event (inflammation) that is common to many diseases.
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