This Brief provides an overview and history of the definition of serial homicide, from the perspectives of psychology, medicine, criminology and forensics. It reviews research to provide a standard definition of serial homicide (as opposed to multiple or mass homicide), and provide insights on profiles of victims and offenders for police practitioners. It also includes a discussion of the media approach to covering serial homicide. The Brief is divided into four major sections covering: definitions and overview of serial homicide, profiling perpetrators according to different typologies, profiling victims, applied case studies, and recommendations for investigation and prevention. The author's approach is aimed primarily at researchers in police studies, but will be of interest to researchers in related fields such as criminal justice, sociology, psychology, and public policy.