Despite the lack of guidance available for practitioners, extensive polypharmacy has become the primary method of treating patients with severe and chronic mood, anxiety, psychotic or behavioral disorders. This ground-breaking new book provides an overview of psychopharmacology knowledge and decision-making strategies, integrating findings from evidence-based trials with real-world clinical presentations. It adopts the approach and mind-set of a clinical investigator and reveals how prescribers can practice 'bespoke psychopharmacology', tailoring care to the individualized needs of patients. Practitioners at all levels of expertise will enhance their ability to devise rationale-based treatments, targeting manifestations of dysfunctional neural circuitry and dimensions of psychopathology that cut across conventional psychiatric diagnoses. Presented in a user-friendly, practical, full-colour layout and incorporating summary tables, bullet points, and illustrative case vignettes, it is an invaluable guide for all healthcare professionals prescribing psychotropic medications, including psychiatry specialists, primary care physicians, and advanced practice registered nurses.

This new edition of The American Psychiatric Association Publishing Textbook of Mood Disorders is a systematic and painstaking reconceptualization of its predecessor. Under new editorial direction and with a revised roster of expert contributors, the second edition is an utterly current, clinically competent, and comprehensive text that will become an instant classic. The book is structured for learning and easy reference, moving deftly from symptomatology and epidemiology to pathogenesis and on to somatic interventions, cognitive-behavioral interventions, and psychotherapy. The latest science on genetics and epigenetics, brain imaging, and neurobiology are also examined in depth. Critically important to the clinician is the section on management of mood disorders, which provides treatment guidelines for major depressive disorder and bipolar disorder, as well as information on understanding, and preventing, suicide in children, adolescents, and adults. Finally, perspectives are offered on depression among women, children, and geriatric patients, as well as on depression across cultures. Practicing psychiatrists, residents, and students alike will benefit from the book's inclusive coverage. Topics new to this edition include the following: * Treatment-resistant depression-its definition and approaches to its treatment-is addressed in a dedicated chapter that covers diagnostic accuracy, pseudoresistance, comorbidity, pharmacological management, adjunctive strategies, psychotherapy, neuromodulation, and novel and experimental therapies.* Investigational agents, most notably ketamine and its relatives, constitute an exciting frontier in the treatment of mood disorders, and the clinical application, routes of delivery, dosing, risks, and clinical trials are explored in a dedicated chapter that is both rigorous and thorough.* There is compelling evidence that childhood maltreatment (defined as exposure to emotional, physical, and sexual abuse and neglect before the age of 18 years) is a prominent risk factor for the development of mood disorders as well as for a pernicious course and poor treatment response in mood disorders. These findings, as well as the underlying neurobiological and environmental interactions that may contribute to the development of mood disorders, are examined thoroughly and thoughtfully.* As our understanding of immune function in mood disorders has grown, psychoneuroimmunology has emerged as a focus of study likely to make major contributions to clinical practice in the coming decades. The book updates readers on this promising area of research. Over the last decade, depression has emerged as the leading cause of disability worldwide, with significant attendant morbidity and mortality. The American Psychiatric Association Publishing Textbook of Mood Disorders equips clinicians and trainees with the knowledge they need to alleviate suffering in their patients with mood disorders.

Mental health is an important public health issue. National survey data indicate that 48% of the U.S. adult population have reported a psychiatric disorder at some point in their lives and 30% have reported one in the past 12 months. With the changing healthcare environment, 60% of these patients are identified and receive treatment in the primary care setting.

"Recognition and Treatment of Psychiatric Disorders: A Psychopharmacology Handbook for Primary Care"- developed to provide the busy primary care physician with practical and timely strategies for screening and treating patients who have psychiatric disorders. It covers- The continually growing number of drugs available for treatment of mental disorders.- An overview of the epidemiology, pathophysiology, presentation, diagnostic criteria, and screening tests for common psychiatric disorders including anxiety disorders, mood disorders, insomnia, somatization disorder, substance use disorder, eating disorders, dementia, and schizophrenia- Treatment algorithms and other step-by-step approaches to direct the physician who is treating patients with mental disorders including drug dosages, schedules, and routes of administration- Basic pharmacology, pharmacokinetics, drug interaction and safety concerns, and practical dosing issues for all classes of drugs used to treat mental disorders- Guidelines for primary care physicians on when to refer patients to psychiatrist colleagues

This handbook is the quintessential resource for primary care physicians needing to screen and treat patients with mental disorders. Brief, but informative, this resource includes a glossary, a listing of printed and electronic mental health resources, a bibliography, and an appendix containing selected diagnostic rating scales.

The American Psychiatric Association Publishing Textbook of Psychopharmacology is an indispensable and comprehensive resource for clinicians and trainees who prescribe psychotropic medications. Updated to reflect the new DSM-5 classification, this revised Fifth Edition maintains the user-friendly structure of its predecessors while offering in-depth coverage of the latest research in pharmacological principles, classes of drugs, and psychiatric disorders. Introductory chapters provide a theoretical grounding in clinical applications, with topics ranging from neurotransmitters to brain imaging in psychopharmacology. The bulk of the book is devoted to various classes of drugs, including antidepressants, anxiolytics, antipsychotics, mood stabilizers, and other agents, with each class divided into chapters on specific drugs-either new or revised to include the latest findings and trends. Finally, the section on psychopharmacological treatment addresses evidence-based principles of clinical care for the full spectrum of mental disorders and conditions-from depression to chronic pain-as well as for specific populations and circumstances-from children and adolescents to psychiatric emergencies-offering information on topics such as medication selection, combination and maintenance dosing regimens, monitoring and management of side effects, and strategies for optimizing treatment response. The book's beneficial features are many: * The section on principles of pharmacology has been revised and reorganized to incorporate recent discoveries from the fields of neurobiology, genetics, brain imaging, and epidemiology.* History and discovery, structure-activity relationships, pharmacological profiles, pharmacokinetics and disposition, mechanisms of action, indications and efficacy, side effects and toxicology, and drug-drug interactions are addressed for each agent. This consistent structure places the desired information at the clinician's fingertips and facilitates study for trainees.* Coverage of drugs approved since the last edition is thorough, encompassing new antidepressants (e.g., vortioxetine), new antipsychotics (e.g., cariprazine), and agents on the clinical horizon (e.g., ketamine).* More than 180 tables and graphs present critically important data in an accessible way. A work of uncommon scientific rigor and clinical utility, The American Psychiatric Association Publishing Textbook of Psychopharmacology provides state-of-the-art information on both the principles and the practice of psychopharmacological treatment of psychiatric disorders.