This book brings together the work of more than 25 scholars from different parts of the world who analyze the challenges posed by the new coronavirus and how it can transform the lives of the cities. Through 19 chapters organized into three sections - experiences, responses and uncertainties - the authors offer a novel perspective about the resilience of the metropolis to face the most important sanitary crisis in the twenty-first century. History shows that cities can innovate and change profoundly in a response to disasters or after suffering an intense crisis, such as a pandemic or dramatic local spread of infectious diseases. In many cases, cities evolve to better urban systems, as literature based on the resilience perspective suggests. From this perspective, this book is a unique contribution to the academic discussion offering a multidisciplinary approach to analyze the impact of COVID-19 in the cities.