Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.

This book draws a connection between ethics and research across social sciences, philosophy, medical sciences and legal sciences, and demonstrates that any research activity needs to be conducted by means of rules deriving from the field of ethics. Although having a common core, such rules assume different characteristics depending on the branch of science, as the contributions on philosophy, medicine, dentistry, law, biotechnology, robotics and architecture highlight. It also investigates the more complex ethical concerns and places them in a larger, technological context. Starting with an introduction to common-sense ethical principles, the contributions then guide the reader, helping them develop and understand a comprehensive knowledge on the field. Notably, it appeared interesting to analyze recent events related to the arrival of the Sars-CoV-2 pandemic in light of ethical principles, highlighting in what terms their applicability can still be confirmed. Moreover, the book makes these topics accessible to a non-expert audience, while also offering alternative reading pathways to inspire more specialized readers.

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Student communities are without doubt a strategic resource for urban development and students are the citizens and the high-skilled working class of tomorrow. They are seen as an 'invisible population' with little say in local policy and decision-making. Co-operation between educational institutions and city planners is often missing and cities tend to neglect the universities' foreign relations. This volume argues that the importance of human capital in the competitiveness of cities demands pro-active, integral city policies targeting this community. Bringing together nine case studies of European cities (Rotterdam, Utrecht, Eindhoven, Munich, Lyon, Lille, Venice, Birmingham and Helsinki), it puts forward a comprehensive strategic plan of action, aiming at the integration of student communities in urban development. The book analyses the essential characteristics of the relationship between students and their host communities, as well as the role of higher education institutions and other actors in building the 'student friendly' city.

Student communities are without doubt a strategic resource for urban development and students are the citizens and the high-skilled working class of tomorrow. They are seen as an 'invisible population' with little say in local policy and decision-making. Co-operation between educational institutions and city planners is often missing and cities tend to neglect the universities' foreign relations. This volume argues that the importance of human capital in the competitiveness of cities demands pro-active, integral city policies targeting this community. Bringing together nine case studies of European cities (Rotterdam, Utrecht, Eindhoven, Munich, Lyon, Lille, Venice, Birmingham and Helsinki), it puts forward a comprehensive strategic plan of action, aiming at the integration of student communities in urban development. The book analyses the essential characteristics of the relationship between students and their host communities, as well as the role of higher education institutions and other actors in building the 'student friendly' city.

Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research. The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy.

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.

Plucked from his beloved Italian country-side, severed from his family, and placed on an ocean liner in the bay of Naples, Antonio Russo, just ten years old, embarks on the journey of his life. As he steps foot onto New York soil with not a word of English, his pockets stuffed with salami and provolone cheese and wearing a pair of shoes for the occasion, Antonio recalls the promise from his mother that in America he would find family members to take care of him and the trees blossoming with gold. This young Italian boy finds himself hit hard with a large dose of reality, obstacles at every turn. These obstacles would become the demons with which Antonio finds himself doing constant battle, but as fate would have it, he one day comes to realize that he is good at something. He finds by chance that he has a natural instinct and ability in the sport of wrestling. As his story unfolds, it would be the sport of wrestling that ignites a passion and guides him to the realization of his true potential, giving meaning to the struggle he and his family would endure in their journey from Southern Italy to the United States to create a better way of life.

This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.