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Confidence Intervals for Discrete Data in Clinical Research is
designed as a toolbox for biomedical researchers. Analysis of
discrete data is one of the most used yet vexing areas in clinical
research. The array of methodologies available in the literature to
address the inferential questions for binomial and multinomial data
can be a double-edged sword. On the one hand, these methods open a
rich avenue of exploration of data; on the other, the wide-ranging
and competing methodologies potentially lead to conflicting
inferences, adding to researchers' confusion and frustration and
also leading to reporting bias. This book addresses the problems
that many practitioners experience in choosing and implementing fit
for purpose data analysis methods to answer critical inferential
questions for binomial and count data. The book is an outgrowth of
the authors' collective experience in biomedical research and
provides an excellent overview of inferential questions of interest
for binomial proportions and rates based on count data, and reviews
various solutions to these problems available in the literature.
Each chapter discusses the strengths and weaknesses of the methods
and suggests practical recommendations. The book's primary focus is
on applications in clinical research, and the goal is to provide
direct benefit to the users involved in the biomedical field.
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