This book constitutes the proceedings of the 11th International Conference on Computational Methods in Systems Biology, CMSB 2013, held in Klosterneuburg, Austria, in September 2013. The 15 regular papers included in this volume were carefully reviewed and selected from 27 submissions. They deal with computational models for all levels, from molecular and cellular, to organs and entire organisms.

Dental caries is a transmittable infectious disease with a central role of bacteria instrumenting the onset of caries formation. Human oral cavity harbours numerous microbes which are not yet been able to culture or investigate. The present study was aimed to characterize the microbial population associated with the dental caries using culture dependent and culture independent approaches. Various biochemical characterization including Biofilm Formation analysis, Antibiotic Assay and 16s rRNA gene amplification were performed to investigate the culture dependent analysis of microbial flora associated with dental caries. Biofilm formation test revealed that the oral bacterial strains formed better biofilms. Also, molecular approach of recombinant DNA technology (Metagenomics) was employed for culture independent analysis of microbial flora associated with dental caries.

An seismic classification system was designed for the recognition of different vehicle categories: wheeled and tracked vehicle. The focus of this research was to study the usability of seismic features for distinction between these classes in traffic scenarios which include low and high vehicle's velocity and a combined traffic situation.classification system can be extended in a way that extracted features are utilized as characteristic fingerprints, which affords tracking of vehicles over multiple sensor nodes.

This work describes the fundamentals of CORDIC (Co- ordinate rotation Digital Computer) algorithm and how CORDIC algorithm can be used to calculate the trigonometric functions (Sine and Cosine) in circular rotation mode. The value of Sine and cosine functions are calculated in IEEE-754-1985 standardized single precision floating point format for better precision, accuracy and portability in the result. A normalization scheme is used which reduces error and requires no extra hardware. The trigonometric function values calculated using CORDIC algorithm are implemented in VHDL (Very High Speed Hardware Description Language), including language and design issues. The algorithm has been implemented in FPGA using VHDL.