A large number of chemical agents are known which affect blood and blood-forming organs. The purpose of this volume is to review the sig- nificant advances made over the past several years regarding such chemical agents. The purification, biological action, and therapeutic implications of several widely used hematopoietic growth factors such as interleukin 3 (IL-3 or multi-CSF), granulocyte/macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), colony stimu- lating factor (CSF-I or M-CSF), thrombopoietin, and erythropoietin are included in this volume. These factors are important in regulating several hematopoietic cell lines such as neutrophils, monocytes, eosinophils, macrophages, megakaryocytes, platelets, and erythrocytes. People are exposed daily to numerous toxic chemical substances present in our environment which produce a suppression of erythropoiesis, myelo- poiesis, lymphocytopoiesis, and megakaryocytopoiesis. Attempts have been made in this volume to assess the therapeutic role of some of the hematopoietic factors such as erythropoietin in the anemia of end stage renal disease, as well as colony stimulating factors in other hematopoietic abnormalities. In addition, some of the chemical factors in our environment which suppress major hematopoietic lineages stimulated by erythropoietin, macrophage colony stimulating factor, granulocyte colony stimulating factor, interleukin I-alpha, interleukin I-beta, and interleukins 2, 3, 4, 5, 6, 7, and 9 are also included. An updating of the mechanism of action of each of these factors on the major hematopoietic lineages is covered.

This thesis examines the impact that the dominant personalities of General Douglas MacArthur and Admiral Ernest King had in shaping Allied strategy in the Pacific during the Second World War. The concept of dominant personality is defined as containing three essential elements: arrogance, tenacity, and supreme competence. The lives of MacArthur and King are examined, demonstrating that the actions of each consistently reflected these characteristics, allowing them to dominate those around them. Three key decisions from the Pacific war are scrutinized for the impact of one or both of these dominant personalities. King and MacArthur affected these decisions in different ways. In the first, the decision to initiate carrier raids against Japan in early 1942, King acted unopposed in pushing his audacious plans through. The second decision was to invade Guadalcanal (Operation Watchtower) in August 1942. King and MacArthur drove this decision in parallel competition, each striving to begin offensive operations and each desiring to be in control. Finally, the long competition between the Central and Southwestern Pacific drives for primacy, culminating with the debate over invading Luzon or Formosa, is examined. In this case, MacArthur and King pursued mutually exclusive courses and stalemate nearly resulted.